The Tretinoin Patient Information Leaflet – Skin+Me Essentials

This document contains important information about using your treatment. Before you apply
your first dose, please read all of the following information.
This documents refers to the following topical preparations:

Tretinoin 0.006% serum
Tretinoin 0.012% serum
Tretinoin 0.024% serum

In this Information Leaflet, you’ll find:

General treatment information
Contraindications
Information about your active ingredients and the base serum
Storage instructions and guidance
How to report side effects

1. General treatment information

Your Skin + Me Essentials tube contains approximately 8ml of serum compounded by The
Feel Good Pharmacy, Unit 5 Oakwood Business Park, Standard Road, London, NW10 6EX.
The treatment has been prescribed for your skin, and only your skin. Please don’t share this
treatment with anyone else, as it may cause harm

Application + Usage

● Your treatment is only ever for external use.
● Wash hands before and after you apply your treatment.
● Wash your face, and allow your skin to completely dry.
● One dose is to be used once a day, at night time. Gently squeeze 5.5cm
(approximately 0.28ml) of serum onto a clean finger. Use the measuring guide
provided in your Daily Serum pack to measure out the recommended dose.
● Do not use more treatment than prescribed, or more often or for longer than
instructed. Doing so can increase your chances of experiencing side effects.
● Apply a thin layer of the serum to your whole face, avoiding the immediate eye area
and mouth. Do not apply to any areas of broken skin.
● Do not swallow your serum.
● If you miss a dose, just apply the following evening. Don’t double up on applications.
● It can take several weeks before you see initial improvements in your skin. The
prescribed treatment plan should be followed as directed by your Prescriber.
● Do not use your serum past the expiry date printed on the label of your treatment.

2. Contraindications

Treatments containing Tretinoin should NOT be used if you are pregnant,
breastfeeding or trying to conceive

Do not use your treatment if you have a known allergy to any of the active ingredients or to
the base serum (see section 3).

If you develop an allergic reaction to your treatment then you must stop applying it. For your
reference, signs of an allergic reaction may include rash; hives; itching; shortness of breath;
wheezing; cough; swelling of the face, lips, tongue or throat.

If in doubt, do not hesitate to ask your doctor or pharmacist for advice and call 999 in a
medical emergency.

3. Information about your active ingredients and the base serum

3a. Tretinoin – warnings and precautions

Side effects: There may be a brief initial sensation of warmth or stinging immediately after
applying this medication. Local side effects such as dry skin, redness, itching, rashes,
irritation and mild peeling are common (seen in between one in 10 and one in 100 users).
These effects tend to settle with time. There is also a small chance of an initial flare of acne
and its associated complications including scarring. More severe side effects such as
swelling, blisters, skin burning sensation, eye irritation, skin discolouration, crusting and
significant skin peeling may occur uncommonly (seen in between one in 100 and one in
1000 users). Rarely skin hyperpigmentation (darkening of the skin) and hypopigmentation
(lightening of the skin) and severe allergic reactions can occur (seen in between one in 1000
and one in 10, 000 users).
There have been 3 case reports of topical Tretinoin being associated with the development
of Idiopathic Intracranial Hypertension. There is no evidence proving it can cause it but if you
have this condition you may not want this treatment and you should stop treatment and
speak to your GP or healthcare provider if you do develop any symptoms. If you experience
any of these more serious skin reactions please stop treatment and contact us for further
advice, or speak to your GP or healthcare provider.

Do not use if your skin is sunburned.

You may find that your skin is more sensitive to sunlight and sunburns more easily with
Tretinoin use. An appropriate sunscreen (minimum SPF 30 with UVA and UVB protection)
and/or protective clothing should be used daily whenever applying tretinoin. Avoid using
sunbeds, tanning lamps and strong sun.

Avoid using exfoliating products, soaps/cleaners with a strong drying effect, alcohol products
and scented facial products as this may further irritate your skin. Avoid waxing whilst using
this treatment.

WARNING: TRETINOIN MAY CAUSE HARM TO AN UNBORN BABY IF USED WHILE
PREGNANT. IF YOU ARE PREGNANT, BECOME PREGNANT OR ARE PLANNING A
PREGNANCY WHILST USING THIS MEDICATION OR WITHIN ONE MONTH AFTER
STOPPING TREATMENT, PLEASE CONTACT YOUR DOCTOR. PLEASE ENSURE
ADEQUATE CONTRACEPTION IS TAKEN WHILST USING THIS MEDICATION AND
STOP ONE MONTH BEFORE TRYING TO CONCEIVE.

Our base serum

Base serum ingredients: Aqua, Propylene Glycol, Ethanol, Isopropyl palmitate, Dimethicone,
Glycerin, Ectoin, Polyacrylate Crosspolymer-6, Polysorbate 80, Polysilicone-11,
Ethylhexylglycerin, Butylene Glycol, Phenoxyethanol, Disodium EDTA, Butylated
hydroxytoluene (BHT), Decyl Glucoside, Hexylene Glycol and Caprylyl Glycol.

4. Storage instructions and guidance

KEEP THIS MEDICATION OUT OF SIGHT AND REACH OF CHILDREN.

Do not flush unused medication or pour it down the sink, and do not place it in the general
waste bin. Please ask your pharmacist what to do with unused medication. These measures
are in place to help the environment.

Store in a cool dry place below 25-degree Celsius and out of direct sunlight.

Do not use your medication after the expiry date which is shown on the packaging

5. How to report side effects

If you experience any unwanted side effects, you should contact us via the Dermatology
Support team or talk to your GP or healthcare professional. Also, you can help to make sure
medicines remain as safe as possible for everyone by reporting any unwanted side effects
directly via www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play
or Apple App Store.

Last update: 27/08/2026